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Observe Carefully (one)pentobarbital will minimize the extent or impact of glecaprevir/pibrentasvir by impacting hepatic/intestinal enzyme CYP3A4 metabolism.Watch Closely (1)pentobarbital will lower the level or effect of fentanyl intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Coadministration